Beyond End Protection: Shelterin, POT1 Dysfunction, and Telomere Replication Stress in Cancer
Tadahiko Matsumoto, Akifumi Takaori-Kondo · 2026
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Description
Tadahiko Matsumoto and Akifumi Takaori-Kondo reviewed chromosome end guards and cancer in a 2026 paper. Telomeres cap the ends of chromosomes and are guarded by a protein shell called shelterin. Their repeat-rich build makes them hard to copy, so copying stress builds up at the ends with each cell split.
One guard, POT1, fails in some cancers, and those faults tilt cells toward growth. The review sums up how ends are copied and kept, where the stress comes from, and how POT1 faults drive disease. It also weighs drugs that aim at end biology. Such drugs could strike cancers that lean on faulty end care.
Catalog record
| CREATOR | Tadahiko Matsumoto, Akifumi Takaori-Kondo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |