Genetic Evidence for a Putative B Cell–Cholate Immunometabolic Axis in Pericarditis: A Mendelian Randomization Study
Yifei Zhang, Wuxiao Yang, Xuewen Li · 2026
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Description
Yifei Zhang, Wuxiao Yang, and Xuewen Li use genetics to test whether immune cells and blood metabolites in fact cause pericarditis, the inflammation of the heart's sac. Links seen in plain studies cannot separate cause from coincidence. Mendelian randomization uses inherited variants as natural experiments. Their two-sample design drew on public genome-wide data.
Forward analysis found twenty-nine immune traits with genetically predicted associations to pericarditis. Reverse analysis checked the other way. A two-step mediation analysis then asked whether metabolites carry part of the immune effect. The headline pathway links a B cell trait through cholate, a bile-related metabolite, to disease risk. Sensitivity analyses supported the main findings. The team frame the axis as a hypothesis for targeted follow-up.
Catalog record
| CREATOR | Yifei Zhang, Wuxiao Yang, Xuewen Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |