Heterogeneity in Clinicopathological and PD-L1 Expression Profiles Across Mismatch Repair Protein Deficiency Patterns in Endometrial Carcinoma
Yunyun Xiao, Hao Yu, Danyu Huang, Shijia Liu, Yaping Wang, Ran Ren, Hanfu Hu, Shuoyan Wang, Haoyu Yu, Yi Li, Lu Han · 2026
Read Heterogeneity in Clinicopathological and PD-L1 Expression Profiles Across Mismatch Repair Protein Deficiency Patterns in Endometrial Carcinoma by Yunyun Xiao, Hao Yu, Danyu Huang, Shijia Liu, Yaping Wang, Ran Ren, Hanfu Hu, Shuoyan Wang, Haoyu Yu, Yi Li, Lu Han (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13604280.txt.
Description
Yunyun Xiao and co-authors compare repair protein loss patterns in womb lining cancer in a 2026 study. Some tumors lose DNA mismatch repair, and the exact proteins lost vary. The team asked whether those patterns track with clinical traits and with a marker that guides immune therapy.
Records covered 675 patients treated from 2017 to 2025. Of these, 502 tumors kept repair and 173 lost it, split into three loss pattern groups. Repair lost tumors showed lower body mass, higher grade, and more spread into vessel spaces, plus higher marker levels. A newer staging system caught their local aggression better than the older one. Marker scores also differed within the loss groups.
Catalog record
| CREATOR | Yunyun Xiao, Hao Yu, Danyu Huang, Shijia Liu, Yaping Wang, Ran Ren, Hanfu Hu, Shuoyan Wang, Haoyu Yu, Yi Li, Lu Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |