Molecular Characterization of Colistin Resistance Acinetobacter baumannii Isolates and Identification of Mutations in pmrA and lpxA Genes from a Tertiary Care Hospital in South India
MuthuLakshmi BackiaSubramanian, Madhumala Shanmugasundaram, Shanthi Mariappan, Uma Sekar, Renuka M K, Thyagarajan Ravinder · 2026
Read Molecular Characterization of Colistin Resistance Acinetobacter baumannii Isolates and Identification of Mutations in pmrA and lpxA Genes from a Tertiary Care Hospital in South India by MuthuLakshmi BackiaSubramanian, Madhumala Shanmugasundaram, Shanthi Mariappan, Uma Sekar, Renuka M K, Thyagarajan Ravinder (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13603742.txt.
Description
MuthuLakshmi BackiaSubramanian, Madhumala Shanmugasundaram, and Shanthi Mariappan lead a team hunting the genetic changes behind colistin resistance in a feared hospital germ. Their study appeared in two thousand twenty-six. The germ resists most first-line drugs, leaving colistin as a last resort. Resistance to that last line is now emerging, including in India.
The team analyzed over two hundred clinical isolates from a South Indian hospital. Only a handful resisted colistin, but all of those resisted strongly. Gene checks found changes in two genes that alter the cell surface colistin targets. A plasmid-borne resistance gene was also screened for. Such mutations explain resistance that travels poorly but arises under drug pressure. The authors stress how few India-focused mechanism studies exist. Their data guide local surveillance and stewardship.
Catalog record
| CREATOR | MuthuLakshmi BackiaSubramanian, Madhumala Shanmugasundaram, Shanthi Mariappan, Uma Sekar, Renuka M K, Thyagarajan Ravinder |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |