Synthetic Cyclic C5-Curcuminoids Mitigate Oxidative, Apoptotic and Inflammatory Damage in a 6-OHDA-Induced Neuron–Microglia Co-Culture Model of Neuronal Damage
Edina Pandur, Zsombor Bence Tóth, Levente Tyukodi, Ilona Gróf, Szilvia Veszelka, Mária A. Deli, Zsuzsanna Rozmer, Imre Huber · 2026
Read Synthetic Cyclic C5-Curcuminoids Mitigate Oxidative, Apoptotic and Inflammatory Damage in a 6-OHDA-Induced Neuron–Microglia Co-Culture Model of Neuronal Damage by Edina Pandur, Zsombor Bence Tóth, Levente Tyukodi, Ilona Gróf, Szilvia Veszelka, Mária A. Deli, Zsuzsanna Rozmer, Imre Huber (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13603456.txt.
Description
Eight researchers in Hungary test lab made curcumin relatives on neuron damage in a 2026 paper. Curcumin from turmeric fights oxidation and inflammation, yet it breaks down fast in the body. Ring shaped variants are sturdier, so the team made seven of them for study.
A toxin that mimics Parkinson style harm was applied to neuron and microglia cells grown together. Four compounds cut harmful oxygen species by a third to a half and raised antioxidant capacity by large margins. Enzyme defenses also rose in the treated cells. Three compounds calmed the microglia side as well. Death pathway markers, including an iron driven form, are tracked across the tests.
Catalog record
| CREATOR | Edina Pandur, Zsombor Bence Tóth, Levente Tyukodi, Ilona Gróf, Szilvia Veszelka, Mária A. Deli, Zsuzsanna Rozmer, Imre Huber |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |