Carnosine Potentiates a Compensatory Mitochondrial–Synaptic Proteomic Response in the ALS Cerebellum
Hellen P. Valerio, Valeria Oliveira, Stephanie Y. Ferreira, Isabel R. Pereira, Giuseppe Palmisano, Mariana P. Massafera, Vanderson S. Bispo, Fernanda M. Prado, Paolo Di Mascio, Marisa H. G. Medeiros · 2026
Read Carnosine Potentiates a Compensatory Mitochondrial–Synaptic Proteomic Response in the ALS Cerebellum by Hellen P. Valerio, Valeria Oliveira, Stephanie Y. Ferreira, Isabel R. Pereira, Giuseppe Palmisano, Mariana P. Massafera, Vanderson S. Bispo, Fernanda M. Prado, Paolo Di Mascio, Marisa H. G. Medeiros (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13603265.txt.
Description
Hellen Valerio and nine colleagues measured how carnosine, a peptide, reshapes proteins in the cerebellum of rats that model ALS. It asks what carnosine does to the proteins of this part of the brain. ALS is a fatal disease. It kills motor neurons amid chronic swelling. Carnosine can clear reactive carbonyls, mop up free radicals, and bind zinc. The rats carried the SOD1 mutation that models the disease. The team mapped proteins in the cerebellum with proteomics, comparing rats given it with rats given none.
The peptide changed protein networks. The changes touched mitochondria, cell stress defenses, and signal packet traffic. Receptor subunits for go and stop transmitters rose, several beyond healthy levels. Paths for vesicle cycling were turned up. The pattern looks like a backup plan: the cerebellum shores up its synapses as disease advances elsewhere. The 2026 study names it a candidate support therapy worth testing.
Catalog record
| CREATOR | Hellen P. Valerio, Valeria Oliveira, Stephanie Y. Ferreira, Isabel R. Pereira, Giuseppe Palmisano, Mariana P. Massafera, Vanderson S. Bispo, Fernanda M. Prado, Paolo Di Mascio, Marisa H. G. Medeiros |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |