Modelling Olfactory Dysfunction in Rodents Through Intranasal Vanadium Exposure
Margarida Pereira, Sofia Alves-Pimenta, Carlos Venâncio, Maria de Lurdes Pinto, Bruno Colaço · 2026
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Description
Margarida Pereira and co-authors reviewed this 2026 rodent model of smell loss caused by a metal pollutant. Vanadium, inhaled through the nose, can ride the smell pathway straight into the brain. That route makes it a useful lab stand-in for pollution-driven smell damage. The review gathers what rat and mouse studies show about the whole smell system under this exposure.
Damage centers on oxidative stress, failing mitochondria, inflammation, and dying neurons, from the nose lining to brain centers. The authors cover delivery methods, body changes, and behavior effects. Gaps remain around whether the smell lining can regrow and recover function. A clear model matters because smell loss often precedes wider brain disease, and pollution exposure is hard to study directly in people.
Catalog record
| CREATOR | Margarida Pereira, Sofia Alves-Pimenta, Carlos Venâncio, Maria de Lurdes Pinto, Bruno Colaço |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |