The Proteasome Safeguards Red Blood Cell Integrity During Storage and After Transfusion
Sandy Peltier, Théo Michel, Fanny Mialane, Mickaël Marin, Michaël Dussiot, Céline Rodriguez, Monika Dzieciatkowska, Marie Tamagne, Camille Roussel, Stéphanie Vicca, Olivier Hermine, Pierre A. Buffet, Benoit Vingert, Steven L. Spitalnik, Angelo D’Alessandro, Michel Prudent, Pascal Amireault · 2026
Read The Proteasome Safeguards Red Blood Cell Integrity During Storage and After Transfusion by Sandy Peltier, Théo Michel, Fanny Mialane, Mickaël Marin, Michaël Dussiot, Céline Rodriguez, Monika Dzieciatkowska, Marie Tamagne, Camille Roussel, Stéphanie Vicca, Olivier Hermine, Pierre A. Buffet, Benoit Vingert, Steven L. Spitalnik, Angelo D’Alessandro, Michel Prudent, Pascal Amireault (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13603181.txt.
Description
Sandy Peltier and co-authors show that a cellular recycling machine protects stored red blood cells from falling apart. Donated red cells age in the bag under metabolic and oxidative stress, which limits how well transfusions work. Lacking a nucleus, red cells lean heavily on the proteasome, the machine that chews up damaged proteins, to stay orderly.
Blocking that machine during storage drained the cells' energy stores and warped their shape without immediate oxidative harm. When the blocked cells were returned to body-like conditions, damage cascaded: energy crashed, proteins clumped, cells stiffened, burst, and showed eat-me signals, above all in long-stored cells. Naturally old red cells from the body behaved the same way, with low proteasome activity. The authors name proteasome failure a hallmark of red cell aging.
Catalog record
| CREATOR | Sandy Peltier, Théo Michel, Fanny Mialane, Mickaël Marin, Michaël Dussiot, Céline Rodriguez, Monika Dzieciatkowska, Marie Tamagne, Camille Roussel, Stéphanie Vicca, Olivier Hermine, Pierre A. Buffet, Benoit Vingert, Steven L. Spitalnik, Angelo D’Alessandro, Michel Prudent, Pascal Amireault |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |