Structural biology of the TRPM4 channel: architecture, modulation, and therapeutic opportunities
Ingrid Araya-Durán, Marena Rein, Daniella Delgado, Alejandro Yévenes, Victoria Flores del Pino, Fernando González-Nilo · 2026
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Description
TRPM4 is a channel that turns calcium signals inside cells into electrical ones, letting sodium and potassium pass while blocking calcium itself. Araya-Durán and co-authors review the new structural picture of this channel, built from cryo-electron microscopy images that caught it closed, mid-change, open, and drug-bound. They map how calcium sensing, fat signals, and blocking molecules all meet at shared control points.
Faulty TRPM4 shows up in heart rhythm disease, brain swelling after injury, and several cancers. The authors argue the goal is no longer just switching the channel on or off, but holding the right shape in the right tissue. Tiny engineered binders may do that job.
Catalog record
| CREATOR | Ingrid Araya-Durán, Marena Rein, Daniella Delgado, Alejandro Yévenes, Victoria Flores del Pino, Fernando González-Nilo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |