Potassium channels as an ionic checkpoint in tumor immunity
Huanle Wang, Yinan Zhang, Sufen Jiang, Xiaojiang Li, Yixin Zheng, Yukun Wang, Yue Xu, Cong Xia, Yan Yan · 2026
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Description
Huanle Wang and co-authors review the idea that potassium channels act as an ionic checkpoint in tumor immunity, in a paper published in 2026. These channels let potassium flow across cell membranes, which sets the electrical state immune cells need to switch on, move, and attack. Inside solid tumors, that balance is easily upset.
Crowded potassium, low oxygen, and acid build-up inside tumors can stall immune cells before they start their attack signals. The review follows the main channel types in killer cells, helper cells, and other immune players, in both outer membranes and inner cell parts. Because the same channel can help immune cells yet also help tumor cells, blanket switching on or off will not work. The authors call for precise, cell-targeted delivery and better markers.
Catalog record
| CREATOR | Huanle Wang, Yinan Zhang, Sufen Jiang, Xiaojiang Li, Yixin Zheng, Yukun Wang, Yue Xu, Cong Xia, Yan Yan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |