HONU: A Multicenter, Prospective, Observational Study of the Progression of Intermediate Age-Related Macular Degeneration
Robyn H. Guymer, Zhichao Wu, Simon S. Gao, Miao Zhang, Verena Steffen, Chen Chen, Jiameng Zhang, Katie M. Litts, Michael C. Chang, Justin Elstrott, Brian Yaspan, Seema Datta, Jeffrey R. Willis, Liang Liu, Hao Chen, HONU investigators · 2026
Read HONU: A Multicenter, Prospective, Observational Study of the Progression of Intermediate Age-Related Macular Degeneration by Robyn H. Guymer, Zhichao Wu, Simon S. Gao, Miao Zhang, Verena Steffen, Chen Chen, Jiameng Zhang, Katie M. Litts, Michael C. Chang, Justin Elstrott, Brian Yaspan, Seema Datta, Jeffrey R. Willis, Liang Liu, Hao Chen, HONU investigators (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13602060.txt.
Description
Robyn Guymer and co-authors describe HONU, a large observational study of intermediate age-related macular degeneration. Their 2026 paper lays out the design and the enrolled cohort, not treatment results. Four hundred patients joined at seventy-two sites across six countries, each with large drusen and pigment changes in the study eye but no advanced atrophy.
Patients are seen every twelve weeks for up to three years, with detailed eye imaging and new tests of visual function. The study tracks how many eyes convert to advanced atrophic disease and how fast a key retinal layer is lost. Its aim is practical: trials for early disease are now long and huge, and better endpoints could shrink them. HONU's data may show which measures and which patients make future trials feasible.
Catalog record
| CREATOR | Robyn H. Guymer, Zhichao Wu, Simon S. Gao, Miao Zhang, Verena Steffen, Chen Chen, Jiameng Zhang, Katie M. Litts, Michael C. Chang, Justin Elstrott, Brian Yaspan, Seema Datta, Jeffrey R. Willis, Liang Liu, Hao Chen, HONU investigators |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |