Digital signatures of fatigue and wearing-off symptoms in patients with multiple sclerosis under natalizumab
Lars Masanneck, Elaine Trautmann, Judith von Pavel, Ramona Hagler, Marius Vach, Patricia Kirschner, Jan Voth, Melanie Schuette, Pascal Benkert, Jens Kuhle, Jörn Kaufmann, Marie Deffner, Nicholas Schwab, Steffen Pfeuffer, Sven G Meuth, Marc Pawlitzki · 2026
Read Digital signatures of fatigue and wearing-off symptoms in patients with multiple sclerosis under natalizumab by Lars Masanneck, Elaine Trautmann, Judith von Pavel, Ramona Hagler, Marius Vach, Patricia Kirschner, Jan Voth, Melanie Schuette, Pascal Benkert, Jens Kuhle, Jörn Kaufmann, Marie Deffner, Nicholas Schwab, Steffen Pfeuffer, Sven G Meuth, Marc Pawlitzki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13602057.txt.
Description
Lars Masanneck and co-authors present a 2026 study of multiple sclerosis patients on the drug natalizumab. Many patients feel symptoms wear back before the next dose, a pattern called wearing-off. Doctors have not known whether the pattern signals fresh disease activity. The SATURATE study at one center tested that link with blood tests, brain scans, and smartwatch data.
Thirty-four patients took part, and 28 finished six months of follow-up. About two in three felt the wearing-off pattern at some point. The pattern tracked with fatigue scores but not with scan changes or blood markers of nerve harm. Watches gave usable motion data for 21 patients. The results suggest the wearing-off feel may say more about fatigue than about new disease damage, a point that can calm needless alarm.
Catalog record
| CREATOR | Lars Masanneck, Elaine Trautmann, Judith von Pavel, Ramona Hagler, Marius Vach, Patricia Kirschner, Jan Voth, Melanie Schuette, Pascal Benkert, Jens Kuhle, Jörn Kaufmann, Marie Deffner, Nicholas Schwab, Steffen Pfeuffer, Sven G Meuth, Marc Pawlitzki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |