Folate-Targeted polymeric micelles enhance the anti-glioma efficacy of pterostilbene in an orthotopic rat model
Xiaobo Yang, Yuze Sun, Huan Jin, Hailin Zhou, Yunqiao Yang, Yanan Su, Jinan Wang, Zhiwei Zhao, Wenyao Yu, Moli Wu, Qian Wang, Conghongting Liu, Wen Sun, Changyuan Wang, Chong Wang, Li Lv, Mingzhan Li, Jing Ning, Brant E. Isakson, Yinan Wang, Xiaohong Shu · 2026
Read Folate-Targeted polymeric micelles enhance the anti-glioma efficacy of pterostilbene in an orthotopic rat model by Xiaobo Yang, Yuze Sun, Huan Jin, Hailin Zhou, Yunqiao Yang, Yanan Su, Jinan Wang, Zhiwei Zhao, Wenyao Yu, Moli Wu, Qian Wang, Conghongting Liu, Wen Sun, Changyuan Wang, Chong Wang, Li Lv, Mingzhan Li, Jing Ning, Brant E. Isakson, Yinan Wang, Xiaohong Shu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13602055.txt.
Description
Yang and co-authors package a plant compound into targeted micelles that fight brain tumors in rats. Pterostilbene shows brain promise but dissolves poorly and barely reaches the brain. The team built polymer micelles tagged with folate to home to tumor cells. The particles measured about 133 nanometers and loaded drug well. They lifted the compound's apparent solubility 25-fold. In glioma cells bearing folate receptors, uptake and killing beat untargeted micelles.
In rats with tumors grown in the brain, vein dosing raised brain levels. Median survival lengthened over controls. The system shows how targeting can rescue a promising but awkward compound.
Catalog record
| CREATOR | Xiaobo Yang, Yuze Sun, Huan Jin, Hailin Zhou, Yunqiao Yang, Yanan Su, Jinan Wang, Zhiwei Zhao, Wenyao Yu, Moli Wu, Qian Wang, Conghongting Liu, Wen Sun, Changyuan Wang, Chong Wang, Li Lv, Mingzhan Li, Jing Ning, Brant E. Isakson, Yinan Wang, Xiaohong Shu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |