NEMO (IKKγ) citrullination in microglia promotes neuroinflammation in the post-ischemic brain
Sang-A Oh, Song-I Seol, Ja-Kyeong Lee, Il-Doo Kim · 2026
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Description
Sang-A Oh and co-authors find a chemical edit that fans brain inflammation after stroke in a 2026 paper. When a brain artery blocks, immune cells called microglia drive much of the secondary damage. Enzymes called PADs edit proteins by swapping one building block for another, a change named citrullination. In stroke-model mice, the team found edited proteins piling up in activated microglia.
One edited target mattered most: NEMO, a switch protein for the master inflammation pathway. Its editing helped assemble the complex that turns the pathway on. Blocking the enzymes calmed inflammation and protected brain tissue across a wide treatment window. Silencing experiments pinned the work on two enzyme family members. A peptide that blocks the switch's assembly also helped. The authors nominate this edit as a drug target.
Catalog record
| CREATOR | Sang-A Oh, Song-I Seol, Ja-Kyeong Lee, Il-Doo Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |