Role of hypoxia-inducible factor – 1 alpha on the progression of cervical intraepithelial neoplasia and cervical cancer: a narrative review
Yenddy N. Carrero, Jesús A. Mosquera · 2026
Read Role of hypoxia-inducible factor – 1 alpha on the progression of cervical intraepithelial neoplasia and cervical cancer: a narrative review by Yenddy N. Carrero, Jesús A. Mosquera (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13601972.txt.
Description
Yenddy Carrero and Jesus Mosquera review in 2026 how low oxygen drives cervical cancer from early lesions to invasion. A master switch called HIF-1 alpha wakes when oxygen runs thin and turns on genes for new blood vessels, spread, and treatment resistance. The review gathers clinical and lab evidence on that switch in the cervix.
Low-oxygen pockets may appear even before invasion, priming early lesions to turn aggressive, they write. The switch also teams with the virus behind most cervical cancers, a possible synergy. Its gene list spans vessel growth, cell death control, and surface anchors. As a marker it could flag risky lesions; as a target it invites drugs, they argue, though the switch also guards some anti-tumor paths, a balance any therapy must respect.
Catalog record
| CREATOR | Yenddy N. Carrero, Jesús A. Mosquera |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |