Network-orchestrated regulation of thymic dysfunction and restoration
Wenai Sun, Hongbo Chen, Weishan Guo, Qi Guo, Yu Guan, Minghua Li, Gaofeng Qin, Yu Zhang, Wangzhi Wei · 2026
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Description
Wenai Sun and co-authors published this review in 2026. The thymus trains the immune system's T cells, and its slow decay with age weakens immunity in older people. The review frames thymus health as the product of a whole network: the epithelial cells that do the training, the supporting stroma, immune cells, and signals from the wider body. Aging erodes that network layer by layer.
Training cells lose their identity programs, mature poorly, and divide less. The surrounding tissue turns inflamed and oxidatively stressed. Yet the same network can switch into repair mode after acute injury, through special interactions among its cell types. Sex hormone signals form one important node linking body state to thymus condition. The authors argue that single-drug fixes are unlikely to restore a network problem. They favor combined, context-aware strategies that rebuild several layers at once to revive immune function.
Catalog record
| CREATOR | Wenai Sun, Hongbo Chen, Weishan Guo, Qi Guo, Yu Guan, Minghua Li, Gaofeng Qin, Yu Zhang, Wangzhi Wei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |