ApoB-specific CD4+ T cells in atherosclerosis: MHC-II antigen presentation, T cell plasticity, and immune tolerance
Xiaobo Cao, Chongjing Mu, Yi Xu · 2026
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Description
Xiaobo Cao, Chongjing Mu, and Yi Xu review the T cells that target apolipoprotein B, the cargo protein of the fats that clog arteries. Even with strong cholesterol lowering, heart risk stays high, and these immune cells may drive the leftover inflammation. ApoB pieces get shown to CD4 T cells by antigen-presenting cells in the artery wall.
The review covers how that display works and how the responding T cells change character. Early on they can take on calming, regulatory traits. Under high fat loads and late disease, they often shift toward angry, memory-like states. Human studies with custom probes are starting to map these states. The authors weigh vaccines and tolerance tricks tested in mice.
Catalog record
| CREATOR | Xiaobo Cao, Chongjing Mu, Yi Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |