The ER–Golgi intermediate compartment: a central hub integrating membrane trafficking and stress responses
Yingying Guo, Jianfei Zheng, Lei Liu, Shulin Li, Min Zhang, Liang Ge · 2026
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Description
Yingying Guo and five co-authors recast a cell compartment as a hub that joins shipping with stress defense, in a 2026 review. The compartment sits between the cell’s protein factory and its sorting station, and was long seen as a mere pass-through for cargo vesicles. New work gives it a far richer job list.
Beyond sorting cargo both ways, the hub polices protein quality when the factory is stressed and reroutes traffic under strain. It helps build the cell’s recycling sacs, lets some proteins skip the usual exit route during stress, and tunes innate immune signals such as the STING pathway. Viruses, including coronaviruses, hijack it for their own ends. The review pulls these threads into one picture of a control center.
Catalog record
| CREATOR | Yingying Guo, Jianfei Zheng, Lei Liu, Shulin Li, Min Zhang, Liang Ge |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 107 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |