Genomic evidence for putative insertion sequence-associated chromosomal integration of aerobactin virulence loci in ST11 carbapenem-resistant Klebsiella pneumoniae
Na Wang, Xiaocui Peng, Huiying Li, Xiaoyu Li, Chunmei Lei, Bu Wang, Jianhua Liu, Wei Zhang · 2026
Read Genomic evidence for putative insertion sequence-associated chromosomal integration of aerobactin virulence loci in ST11 carbapenem-resistant Klebsiella pneumoniae by Na Wang, Xiaocui Peng, Huiying Li, Xiaoyu Li, Chunmei Lei, Bu Wang, Jianhua Liu, Wei Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13601280.txt.
Description
Na Wang and co-authors (2026) traced how a dangerous bacterium picked up extra virulence. The ST11 line of Klebsiella pneumoniae resists last-line antibiotics, and some members have turned hypervirulent. The textbook route is a fused plasmid carrying virulence genes. Sequencing 112 local resistant isolates and comparing thousands of public genomes, the team found something different in the dominant local lineage.
In most of the hypervirulent local isolates, the virulence region for aerobactin, an iron-gathering system, sat in the chromosome itself. Insertion sequences marked the break points. Those isolates also killed wax moth larvae faster than comparable strains without the arrangement. Global family trees grouped similar strains into one lineage found mostly in China so far. The authors warn that surveillance focused only on plasmids will miss this chromosomal route.
Catalog record
| CREATOR | Na Wang, Xiaocui Peng, Huiying Li, Xiaoyu Li, Chunmei Lei, Bu Wang, Jianhua Liu, Wei Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |