Beyond weight loss: Disentangling the direct effects of semaglutide vs equivalent calorie restriction on reproductive systems of male and female rats
Morgan R Sotzen, Suyeun Byun, Ngozi O Ibadin, Mya A Knappenberger, Madison T Bento, Mohammed Asker, Sergei Koshkin, Francisco J Diaz, Karolina P Skibicka · 2026
Read Beyond weight loss: Disentangling the direct effects of semaglutide vs equivalent calorie restriction on reproductive systems of male and female rats by Morgan R Sotzen, Suyeun Byun, Ngozi O Ibadin, Mya A Knappenberger, Madison T Bento, Mohammed Asker, Sergei Koshkin, Francisco J Diaz, Karolina P Skibicka (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13601064.txt.
Description
Morgan Sotzen and co-authors ask, in 2026, whether a leading obesity drug affects reproduction directly, beyond the weight loss it causes. The drug is now among the most used weight treatments worldwide, and metabolism and fertility are tightly linked. Obese male and female rats received the drug, plain calorie restriction matched to the same weight loss, or neither.
The drug's target was far more present in testes than ovaries, hinting at stronger male effects. After four weeks, both drug and matched restriction improved several sperm measures. Gonad tissue changes mostly suggested better fertility in both sexes. The design lets direct drug effects be separated from weight-loss effects.
Catalog record
| CREATOR | Morgan R Sotzen, Suyeun Byun, Ngozi O Ibadin, Mya A Knappenberger, Madison T Bento, Mohammed Asker, Sergei Koshkin, Francisco J Diaz, Karolina P Skibicka |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |