Spatially Distinct Bone Marrow Sites Are Asymmetrically Impacted by Inflammatory Cardiovascular Disease
Jeroen Deckers, Yuri van Elsas, Iris Versteeg, Tom Anbergen, Yohana C Toner, Cristina Grao-Roldán, Jennifer E Cole, Martin Umali, William Wang, Sheqouia Nauta, Krystyna M Demkiw, Carlos Pérez-Medina, Mandy MT van Leent, Abraham JP Teunissen, Zahi A Fayad, Leo AB Joosten, Filip K Swirski, Matthias Na · 2026
Read Spatially Distinct Bone Marrow Sites Are Asymmetrically Impacted by Inflammatory Cardiovascular Disease by Jeroen Deckers, Yuri van Elsas, Iris Versteeg, Tom Anbergen, Yohana C Toner, Cristina Grao-Roldán, Jennifer E Cole, Martin Umali, William Wang, Sheqouia Nauta, Krystyna M Demkiw, Carlos Pérez-Medina, Mandy MT van Leent, Abraham JP Teunissen, Zahi A Fayad, Leo AB Joosten, Filip K Swirski, Matthias Na (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13601059.txt.
Description
Jeroen Deckers leads a very large team mapping inflammation across the whole skeleton, because bone marrow does not respond to disease as one uniform organ. Cardiovascular disease is increasingly understood as marrow-driven inflammation, yet researchers usually sample one site and generalize. Their method, MarrowMet, injects a radioactive glucose tracer into mice, then measures uptake bone by bone against a whole-body atlas.
Tracer uptake tracked inflammatory activity closely. Applied across models of atherosclerosis, heart ischemia, lung injury, metabolic syndrome, and aging, the maps showed distinct marrow sites lighting up asymmetrically depending on the disease. The atlas then guided which marrow regions to harvest for deeper molecular study. Location, the authors argue, is a variable immunology can no longer average away.
Catalog record
| CREATOR | Jeroen Deckers, Yuri van Elsas, Iris Versteeg, Tom Anbergen, Yohana C Toner, Cristina Grao-Roldán, Jennifer E Cole, Martin Umali, William Wang, Sheqouia Nauta, Krystyna M Demkiw, Carlos Pérez-Medina, Mandy MT van Leent, Abraham JP Teunissen, Zahi A Fayad, Leo AB Joosten, Filip K Swirski, Matthias Na |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |