Exploring the protease inhibitory potential of 2-bromo-2-nitro-1,3- propanediol (Bronopol): Initial findings
Chao Jiang, Gary Krzyzanowski, M. Rohan Fernando · 2026
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Description
Chao Jiang, Gary Krzyzanowski, and Rohan Fernando tested in 2026 whether a common preservative that kills microbes can also block proteases, enzymes that cut proteins. Such blockers are prized tools in research and industry. Four proteases from three families were tested against rising doses of the compound, called Bronopol.
All four lost activity as dose rose, each with its own pattern. One was almost fully blocked at middle doses, while another held out until higher doses. Gel tests showed the compound also protected two test proteins from being cut up. The authors call this a previously unreported activity, with possible uses in labs and industry, pending further study.
Catalog record
| CREATOR | Chao Jiang, Gary Krzyzanowski, M. Rohan Fernando |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |