Flow Cytometric Immune Profiling Enables Early Detection of Rejection in Islet Xenotransplantation
Huu Thanh Le, Erin Fuller, Lauen Joo, Evelyn J Salvaris, Adwin Thomas, Yivee Chew, Min Hu, Francesco Ierino, Mark B Nottle, Peter J Cowan, Wayne J Hawthorne · 2026
Read Flow Cytometric Immune Profiling Enables Early Detection of Rejection in Islet Xenotransplantation by Huu Thanh Le, Erin Fuller, Lauen Joo, Evelyn J Salvaris, Adwin Thomas, Yivee Chew, Min Hu, Francesco Ierino, Mark B Nottle, Peter J Cowan, Wayne J Hawthorne (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13600793.txt.
Description
Huu Thanh Le and co-authors test blood immune checks for early warning of graft rejection in diabetes care. Their 2026 study transplants insulin-making cell clusters from gene-edited pigs into baboons made diabetic. Rejection of such cross-species grafts is the main bar to lasting benefit.
Flow tests counted immune cell types and their active states from tiny blood samples. Counts matched standard blood counts while using tenfold less blood and a third of the time. Seven animals on full drug doses kept graft function for up to 675 days. Three others rejected within two months. Stronger early T-cell calming in the first month linked to long graft survival.
Catalog record
| CREATOR | Huu Thanh Le, Erin Fuller, Lauen Joo, Evelyn J Salvaris, Adwin Thomas, Yivee Chew, Min Hu, Francesco Ierino, Mark B Nottle, Peter J Cowan, Wayne J Hawthorne |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |