Dihydrotestosterone Promotes Hetian Sheep Dermal Papilla Cell Proliferation by Inhibiting the TGF‐β/Smad Signalling Pathway
Qinqin Wang, Xuan Liu, Zhiya Feng, Jianping Zhang, Chunyang Li, Ruijun Shi, Shuwei Li · 2026
Read Dihydrotestosterone Promotes Hetian Sheep Dermal Papilla Cell Proliferation by Inhibiting the TGF‐β/Smad Signalling Pathway by Qinqin Wang, Xuan Liu, Zhiya Feng, Jianping Zhang, Chunyang Li, Ruijun Shi, Shuwei Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13600785.txt.
Description
Wang and co-authors (2026) studied how a male hormone affects the growth cells of sheep hair follicles. Dermal papilla cells sit at the follicle base and steer hair growth. The team isolated these cells from the back skin of newborn Hetian sheep and confirmed their identity with marker stains. They then grew the cells with a range of doses of dihydrotestosterone, the potent form of testosterone.
Growth rose with dose, peaking at the highest dose tested. Gene readings at that dose showed a shifted pattern. The hormone turned up a blocking member of the TGF-beta signaling family. It turned down the growth factor itself, its receptor, and another family member. The pattern suggests the hormone speeds these cells up by damping that pathway. The authors frame the pathway as a key regulator of follicle development and hormone-driven hair growth, with lessons for understanding androgen action in skin.
Catalog record
| CREATOR | Qinqin Wang, Xuan Liu, Zhiya Feng, Jianping Zhang, Chunyang Li, Ruijun Shi, Shuwei Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |