Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 tri
Floriane Le Vilain-Abraham, Jean-Michel Halimi, Patrick Rossignol, Maurice Laville, Michel Azizi, Bénédicte Stengel, Valentin Maisons, Agnès Rouzès, Agnès Caille, Bénédicte Sautenet · 2026
Read Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 tri by Floriane Le Vilain-Abraham, Jean-Michel Halimi, Patrick Rossignol, Maurice Laville, Michel Azizi, Bénédicte Stengel, Valentin Maisons, Agnès Rouzès, Agnès Caille, Bénédicte Sautenet (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13599880.txt.
Description
Floriane Le Vilain-Abraham and co-authors publish the protocol for THINK, a large French trial on blood pressure in kidney disease. High blood pressure drives the heart and kidney damage of chronic kidney disease, yet after the standard first drugs, no evidence favours one next step over another. The authors' hunch is that these patients carry too much fluid, so a water-expelling diuretic should be the second move.
The trial randomises whole centres, forty of them, to either a diuretic-based intensification algorithm or usual care, enrolling 720 patients with moderate to severe kidney disease and uncontrolled pressure. The main endpoint bundles kidney failure, steep kidney decline, cardiovascular events, and death. Blood pressure control, quality of life, and safety are tracked for two years. As a protocol paper, it sets out the design before results exist.
Catalog record
| CREATOR | Floriane Le Vilain-Abraham, Jean-Michel Halimi, Patrick Rossignol, Maurice Laville, Michel Azizi, Bénédicte Stengel, Valentin Maisons, Agnès Rouzès, Agnès Caille, Bénédicte Sautenet |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |