Natural Lactone‐Based Quorum Sensing Inhibitors Attenuate Virulence in Pseudomonas aeruginosa
Shivani Chaturvedi, Ashutosh Sharma, Tanisha Singh, Bibhuti Bhusan Das, Tanmay Dutta, Sunil Kumar Khare · 2026
Read Natural Lactone‐Based Quorum Sensing Inhibitors Attenuate Virulence in Pseudomonas aeruginosa by Shivani Chaturvedi, Ashutosh Sharma, Tanisha Singh, Bibhuti Bhusan Das, Tanmay Dutta, Sunil Kumar Khare (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13599450.txt.
Description
Shivani Chaturvedi and co-authors test in this 2026 study whether natural lactones can disarm a tough germ without killing it. Pseudomonas aeruginosa times its attacks by quorum sensing, a chemical census of its own numbers. The team tried four natural lactones and one lab-made blend on the germ and tracked the attack tools it makes under that census.
The best lactone and the blends cut a key control gene about twofold. Two attack products, a blue pigment and a soapy helper, fell by up to three quarters and one half. Since the germ is disarmed rather than killed, the authors argue, resistance pressure should stay low, a path worth pursuing for biofilm infections.
Catalog record
| CREATOR | Shivani Chaturvedi, Ashutosh Sharma, Tanisha Singh, Bibhuti Bhusan Das, Tanmay Dutta, Sunil Kumar Khare |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |