Associations Between Gut Microbiota and Immune Profiles in Community‐Dwelling Older Adults and the Regulatory Role of Polygonatum odoratum
Tingting Xia, Hongmei Wu, Tianyi Cui, Wenzhi Yang, Min Zhang, Yuhong Huang, Shengyuan Zhou, Yongsheng Wu, Donglan Yan, Fan Jia, Lin Zhang, Zhi Cui · 2026
Read Associations Between Gut Microbiota and Immune Profiles in Community‐Dwelling Older Adults and the Regulatory Role of Polygonatum odoratum by Tingting Xia, Hongmei Wu, Tianyi Cui, Wenzhi Yang, Min Zhang, Yuhong Huang, Shengyuan Zhou, Yongsheng Wu, Donglan Yan, Fan Jia, Lin Zhang, Zhi Cui (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13599344.txt.
Description
Tingting Xia heads a large research team testing whether a traditional Chinese herb, Polygonatum odoratum, can shift gut bacteria and immune aging in older adults. The trial enrolled 140 independently living people aged 60 and above. For 90 days, one group took the herb preparation while the other took a placebo. Blood tests tracked immune cell types, and stool samples mapped gut microbes.
Before treatment began, gut bacteria already tracked with patterns of aged T cells, the immune cells that lose flexibility over time. After 90 days on the herb, the share of worn-out memory T cells fell, helpful bacteria such as Akkermansia grew more common, and Klebsiella declined. Those microbial shifts lined up with better immune readings and fewer chest infections. The authors present the herb as a promising lever on the gut and immune system, while noting the trial shows links rather than proof of cause.
Catalog record
| CREATOR | Tingting Xia, Hongmei Wu, Tianyi Cui, Wenzhi Yang, Min Zhang, Yuhong Huang, Shengyuan Zhou, Yongsheng Wu, Donglan Yan, Fan Jia, Lin Zhang, Zhi Cui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |