Human metapneumovirus prevention in children: emerging roles of monoclonal antibodies and vaccines
Susanna Esposito, Valentina Fainardi, Gaia Giorgia Arnesano, Alberto Argentiero, Nicola Principi · 2026
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Description
Susanna Esposito, Valentina Fainardi, Gaia Giorgia Arnesano, Alberto Argentiero, and Nicola Principi review efforts to prevent a common childhood lung virus. Their narrative review was published in twenty twenty-six. Human metapneumovirus is a top cause of severe chest infection in children, older adults, and the frail.
No licensed vaccine or antibody drug exists yet for it. Work on the virus's fusion protein, the main target of neutralizing immunity, now guides design. Protective antibodies, including some that also block the related RSV virus, worked well in animals, but human testing lags. Vaccines are in progress on five platforms, from weakened live virus to mRNA. The review maps progress and the hurdles that remain before clinics can offer protection.
Catalog record
| CREATOR | Susanna Esposito, Valentina Fainardi, Gaia Giorgia Arnesano, Alberto Argentiero, Nicola Principi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |