Essential Oil Compositions and Biological Activities of Broussonetia papyrifera Aerial Parts: An Integrated In Vitro and In Silico Study
Ty Viet Pham, Nguyen Thi Thoa, Nguyen Thi Huong, Le The Hoai, Tran Quang Hai, Shaza W Shantier, Nguyen Thi Kim Thanh, Phan Hong Minh, Huynh Thi Ngoc Ni, Vo Thi Dung, Ninh The Son · 2026
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Description
Ty Viet Pham and co-authors (2026) profiled the essential oils of the paper mulberry, Broussonetia papyrifera, collected in Vietnam. Oils from stem bark and leaves were dominated by oxygenated sesquiterpenes, with spathulenol the top compound in leaf oil at about a third. The team tested them against cancer cell lines in dishes. Both oils showed moderate killing power. They mopped up free radicals strongly and curbed two inflammation signals, nitric oxide and prostaglandin E2.
Computer predictions added a second lens. The compounds looked drug-like, well absorbed from the gut, and low in predicted toxicity. Docking showed them binding steadily to inflammation enzymes, including both cyclooxygenase forms. The authors conclude the oils are promising antioxidant and anti-inflammatory sources. The combined bench-and-computer design lets each method check the other, a template for screening traditional plants with rich, barely mapped chemistry.
Catalog record
| CREATOR | Ty Viet Pham, Nguyen Thi Thoa, Nguyen Thi Huong, Le The Hoai, Tran Quang Hai, Shaza W Shantier, Nguyen Thi Kim Thanh, Phan Hong Minh, Huynh Thi Ngoc Ni, Vo Thi Dung, Ninh The Son |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |