Progenitor Timing Shapes NG2‐Glia Fate and Oligodendrocyte Differentiation
Ana Cristina Ojalvo‐Sanz, Carolina Pernia‐Solanilla, Laura López‐Mascaraque · 2026
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Description
Ana Cristina Ojalvo-Sanz, Carolina Pernia-Solanilla, and Laura López-Mascaraque trace how birth timing shapes the fate of NG2-glia, a debated brain cell population. Are these cells merely temporary precursors of myelin-making oligodendrocytes, or a self-renewing glial type? The team labeled progenitor cells at four developmental stages in mouse cortex and followed their clones into adulthood.
Progenitors labeled at embryonic day sixteen produced the largest, most widespread NG2-glia clones, still growing between one and three months of age. Newborn-stage progenitors instead favored oligodendrocyte production with weaker NG2-glia maintenance. Mixed clones peaked at the embryonic window too. The authors identify that window as critical for NG2-glia expansion and self-renewal.
Catalog record
| CREATOR | Ana Cristina Ojalvo‐Sanz, Carolina Pernia‐Solanilla, Laura López‐Mascaraque |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |