Microbiota-derived self-adjuvanting exopolysaccharide-based codelivery system for potent cancer immunotherapy
Xuemei Bao, Jiamin Shi, Haochi Zhang, Chunhe Li, Yanchen Liang, Na Pan, Yubing Fu, Xing Su, Wan Wang, Ting Wang, Lipeng Zhang, Xiao Wang · 2026
Read Microbiota-derived self-adjuvanting exopolysaccharide-based codelivery system for potent cancer immunotherapy by Xuemei Bao, Jiamin Shi, Haochi Zhang, Chunhe Li, Yanchen Liang, Na Pan, Yubing Fu, Xing Su, Wan Wang, Ting Wang, Lipeng Zhang, Xiao Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13598176.txt.
Description
Xuemei Bao and co-authors built a cancer vaccine carrier from bacterial sugars that also wakes the immune system, in work published in 2026. Cancer vaccines aim to teach the body's killer cells to attack tumors, but they often falter because the teaching signal and the alarm signal arrive apart. The team's carrier, made of microbe sugars, hauls a tumor protein and a small alarm drug together. It reaches the lymph nodes within hours of injection.
In mouse tests, the vaccine sharply slowed both starting and spread melanoma tumors. It drew killer immune cells into tumors and, paired with a standard immune drug, extended survival further. Two immune pathways fired together to mature the cells that present tumor parts to the killer cells. The authors offer the carrier as a simple, potent base for future cancer vaccines.
Catalog record
| CREATOR | Xuemei Bao, Jiamin Shi, Haochi Zhang, Chunhe Li, Yanchen Liang, Na Pan, Yubing Fu, Xing Su, Wan Wang, Ting Wang, Lipeng Zhang, Xiao Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |