Neuroimaging of indoleamine 2,3-dioxygenase 1 (Ido1) in Alzheimer's disease: Development of a novel 18F-labeled PET tracer
Hua Cheng, Nilay S Narayan, Yongle Wang, Yanli Wang, Yafei Huang, Hongzhi Yang, Ramya Tokala, Jinwu Yan, Joseph William Downey, Anne Siewko, Breanna Lizeth Varela, Madelyn Rose Hallisey, Tiffany A Geronimo, Mary Margaret Banick, Rudolph E Tanzi, Can Zhang, Yulong Xu, Changning Wang · 2026
Read Neuroimaging of indoleamine 2,3-dioxygenase 1 (Ido1) in Alzheimer's disease: Development of a novel 18F-labeled PET tracer by Hua Cheng, Nilay S Narayan, Yongle Wang, Yanli Wang, Yafei Huang, Hongzhi Yang, Ramya Tokala, Jinwu Yan, Joseph William Downey, Anne Siewko, Breanna Lizeth Varela, Madelyn Rose Hallisey, Tiffany A Geronimo, Mary Margaret Banick, Rudolph E Tanzi, Can Zhang, Yulong Xu, Changning Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13598165.txt.
Description
Hua Cheng and a large team of co-authors develop a brain scan tracer for an enzyme tied to inflammation in Alzheimer disease, in a study from 2026. The enzyme, called IDO1, disturbs a chemical pathway in the brain and helps drive inflammation. Yet no scan probe aimed at it in the Alzheimer brain was widely available.
Data analysis first showed that levels of the enzyme track how far the disease has advanced. The team then built a fluorine tagged tracer with a ruthenium based method. The tracer crossed into the brain well and broke down in a favorable way. Scans and tissue tests in a mouse model of the disease showed strong, specific binding. Blocking tests confirmed the signal came from the target enzyme.
Catalog record
| CREATOR | Hua Cheng, Nilay S Narayan, Yongle Wang, Yanli Wang, Yafei Huang, Hongzhi Yang, Ramya Tokala, Jinwu Yan, Joseph William Downey, Anne Siewko, Breanna Lizeth Varela, Madelyn Rose Hallisey, Tiffany A Geronimo, Mary Margaret Banick, Rudolph E Tanzi, Can Zhang, Yulong Xu, Changning Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |