The therapy-conditioned host: a state-transition framework for second primary cancer evolution
Rosiane Batista Mastelari, Tiago Veiras Collares · 2026
Read The therapy-conditioned host: a state-transition framework for second primary cancer evolution by Rosiane Batista Mastelari, Tiago Veiras Collares (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13597459.txt.
Description
Rosiane Batista Mastelari and Tiago Veiras Collares offer a framework for how second cancers grow in people already treated for a first one, in a 2026 paper. Second primary cancers are a growing burden for survivors. Their roots are mixed: inherited risk, shared exposures, aging, and the mutations that treatment itself leaves behind.
The framework treats the patient as a state that treatment perturbs. Before care, the body sits in one state; therapy pushes it into new states that keep evolving, shaped by genes, cell clones, immunity, and tissue condition. Tracking those state changes, the authors argue, explains why second cancers vary so much. The view could guide screening plans tuned to each survivor's treatment history.
Catalog record
| CREATOR | Rosiane Batista Mastelari, Tiago Veiras Collares |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |