Systemic–local immune remodeling in colorectal cancer: CD14+ cell-derived cytokine responsiveness, mucosal immune-cell organization, and exploratory metastasis-associated patterns
Nikolay K. Shakhpazyan, Liudmila M. Mikhaleva, Nikolay K. Sadykhov, Alexandra K. Konyukova, Arkady L. Bedzhanyan, Zarina V. Gioeva, Marina V. Khrustaleva, Elina A. Godzhello · 2026
Read Systemic–local immune remodeling in colorectal cancer: CD14+ cell-derived cytokine responsiveness, mucosal immune-cell organization, and exploratory metastasis-associated patterns by Nikolay K. Shakhpazyan, Liudmila M. Mikhaleva, Nikolay K. Sadykhov, Alexandra K. Konyukova, Arkady L. Bedzhanyan, Zarina V. Gioeva, Marina V. Khrustaleva, Elina A. Godzhello (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13597458.txt.
Description
Nikolay Shakhpazyan and co-authors study immune patterns in colorectal cancer in a 2026 paper. Most past work counts immune cells in tissue or checks fixed inflammation signals. This study instead tests how blood immune cells respond to a stimulus. It also maps immune cells in tissue near and far from the tumor.
The study holds 106 cancer patients and 20 comparison subjects. Blood cells are grown, stimulated, washed, and stimulated again, with four cytokine signals tracked. Cancer links to changed response patterns for two of those signals. Tissue maps and a small metastasis comparison add an exploratory layer to the results.
Catalog record
| CREATOR | Nikolay K. Shakhpazyan, Liudmila M. Mikhaleva, Nikolay K. Sadykhov, Alexandra K. Konyukova, Arkady L. Bedzhanyan, Zarina V. Gioeva, Marina V. Khrustaleva, Elina A. Godzhello |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |