Genetic associations link lung cancer liability to brain imaging phenotypes and nominate an FN1-associated tumor–oligodendrocyte program in small-cell lung cancer
Kai Xu, Peihang Xu, Kunsong Su, Zhenkun Liu, Yang Hao, Hongxiang Feng, Guowei Che, Qinghua Zhou, Xiaoqian Zhai · 2026
Read Genetic associations link lung cancer liability to brain imaging phenotypes and nominate an FN1-associated tumor–oligodendrocyte program in small-cell lung cancer by Kai Xu, Peihang Xu, Kunsong Su, Zhenkun Liu, Yang Hao, Hongxiang Feng, Guowei Che, Qinghua Zhou, Xiaoqian Zhai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13597417.txt.
Description
Kai Xu and co-authors wrote a 2026 paper on links between lung cancer genes and the brain. Lung cancer often spreads to the brain, above all the small-cell type. The team asked whether the genes that raise lung cancer risk also shape brain traits that might invite that spread.
They used a method that plays genes as a natural experiment, comparing cancer data with thousands of brain scan traits. The small-cell type showed the clearest brain links. Digging into public cell data from brain metastases, they pointed to a program involving a protein called FN1 and the brain's support cells. Findings like this may one day help predict which patients face the highest risk of spread to the brain.
Catalog record
| CREATOR | Kai Xu, Peihang Xu, Kunsong Su, Zhenkun Liu, Yang Hao, Hongxiang Feng, Guowei Che, Qinghua Zhou, Xiaoqian Zhai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |