Case Report: Concordance of cerebrospinal fluid-derived circulating tumor DNA with tumor tissue in spinal glioblastoma associated with Lynch syndrome
Carlen A. Yuen, David O. Kamson, Changrui Xiao, William H. Yong, Jennifer E. Soun, Mark Linskey, Michelle Paff, Caressa Hui, Alexander M. Lopez, Yael Freiberg, Hansen Bow · 2026
Read Case Report: Concordance of cerebrospinal fluid-derived circulating tumor DNA with tumor tissue in spinal glioblastoma associated with Lynch syndrome by Carlen A. Yuen, David O. Kamson, Changrui Xiao, William H. Yong, Jennifer E. Soun, Mark Linskey, Michelle Paff, Caressa Hui, Alexander M. Lopez, Yael Freiberg, Hansen Bow (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13597404.txt.
Description
Carlen Yuen and a large team report a rare spinal tumor case where spinal fluid DNA matched tumor tissue. The tumor was a fast brain type growth in the spine of a young man, a spot where biopsy is risky. Fluid tests first flagged the tumor type and a gene risk syndrome.
Tissue tests later confirmed both calls, and germ line tests proved the syndrome. That gene flaw blocks DNA repair and shapes drug choice. The team chose immune therapy based on the full picture. Fluid DNA may guide care when biopsy is hard or unsafe.
Catalog record
| CREATOR | Carlen A. Yuen, David O. Kamson, Changrui Xiao, William H. Yong, Jennifer E. Soun, Mark Linskey, Michelle Paff, Caressa Hui, Alexander M. Lopez, Yael Freiberg, Hansen Bow |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |