Digestive-transformed titanium dioxide nanoparticles disrupt intestinal barrier via mitoxyperilysis mediated by mTOR-cytoskeleton axis dysregulation
Chuxin Zhang, Yiping Liu, Xu Li, Jiaxing An, Wenjing Li, Zhilu Zhou, Yitao Yan, Juan Shao, Zhongyuan Guo · 2026
Read Digestive-transformed titanium dioxide nanoparticles disrupt intestinal barrier via mitoxyperilysis mediated by mTOR-cytoskeleton axis dysregulation by Chuxin Zhang, Yiping Liu, Xu Li, Jiaxing An, Wenjing Li, Zhilu Zhou, Yitao Yan, Juan Shao, Zhongyuan Guo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13597285.txt.
Description
Nine toxicologists trace how a common food additive can tear the gut lining after digestion changes it. Titanium dioxide nanoparticles leave the stomach as dense, protein-coated clumps a micrometer wide, quite unlike the fine particles that went in. The team exposed intestinal cells to these digested clumps and followed the damage step by step.
The clumps overactivated a signaling chain that froze the cell's actin skeleton in place. With the cell's internal scaffolding paralyzed, damaged mitochondria, leaking reactive oxygen, drifted to the cell surface and stayed stuck there. Their concentrated output burned away the membrane's stabilizing fats and flooded it with oxidized lipids until the membrane burst. The authors name this death route mitoxyperilysis and note that it matches none of the known cell death programs. They offer the pathway as a target for making such particles safer.
Catalog record
| CREATOR | Chuxin Zhang, Yiping Liu, Xu Li, Jiaxing An, Wenjing Li, Zhilu Zhou, Yitao Yan, Juan Shao, Zhongyuan Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 96 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |