ASL perfusion radiomic heterogeneity is associated with early mortality in IDH-wildtype glioblastoma, beyond tumor volume: a time-varying effect with tumor-aware DTI-ALPS
Rafail C. Christodoulou, Georgios Vamvouras, Platon S. Papageorgiou, Evros Vassiliou, Elena E. Solomou, Sokratis G. Papageorgiou, Michalis F. Georgiou · 2026
Read ASL perfusion radiomic heterogeneity is associated with early mortality in IDH-wildtype glioblastoma, beyond tumor volume: a time-varying effect with tumor-aware DTI-ALPS by Rafail C. Christodoulou, Georgios Vamvouras, Platon S. Papageorgiou, Evros Vassiliou, Elena E. Solomou, Sokratis G. Papageorgiou, Michalis F. Georgiou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13597259.txt.
Description
A twenty twenty-six study by Rafail C. Christodoulou and six colleagues asked whether texture patterns in perfusion scans predict early death in glioblastoma. The study covered 322 patients with IDH-wildtype grade four tumors. The team extracted radiomic features from arterial spin labeling scans, a contrast-free way to image blood flow. They tested whether feature heterogeneity predicted death after accounting for tumor volume and clinical factors.
Greater scan heterogeneity was linked to death within a year of imaging, with a hazard ratio of 1.39. The link held when tumor volume was modeled several different ways. It also survived a much wider screen of candidate features. A measure of fluid movement along vessel spaces added little. The finding suggests scan texture carries prognostic information beyond tumor size.
Catalog record
| CREATOR | Rafail C. Christodoulou, Georgios Vamvouras, Platon S. Papageorgiou, Evros Vassiliou, Elena E. Solomou, Sokratis G. Papageorgiou, Michalis F. Georgiou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |