Phytosterol-induced modulation of gut microbial bile salt hydrolases ameliorates hyperlipidemia via taurohyodeoxycholic acid-mediated FXR antagonism
Jiayue Xia, Da Pan, Tianyu Wu, Zhiyuan Feng, Yanyan Tian, Zhi He, Zhenzhen Zhang, Yingqi Shao, Junhui Yu, Wei Yan, Jiongnan Wang, Shiyu Yin, Xingyi Jin, Yilu Chen, Yuanyuan Wang, Guiju Sun · 2026
Read Phytosterol-induced modulation of gut microbial bile salt hydrolases ameliorates hyperlipidemia via taurohyodeoxycholic acid-mediated FXR antagonism by Jiayue Xia, Da Pan, Tianyu Wu, Zhiyuan Feng, Yanyan Tian, Zhi He, Zhenzhen Zhang, Yingqi Shao, Junhui Yu, Wei Yan, Jiongnan Wang, Shiyu Yin, Xingyi Jin, Yilu Chen, Yuanyuan Wang, Guiju Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13596926.txt.
Description
Jiayue Xia and co-authors trace how plant sterols may lower blood fats by reshaping gut germs and bile flow, in a study from two thousand twenty-six. Plant sterols are known to cut blood fats, but their path through the gut and liver was unclear. Human data, rat work, germ transplants, and cell tests were combined.
In rats the sterols shifted gut germs and cut the work of a germ enzyme that splits bile salts. A bile acid that blocks a gut sensor then rose in gut and liver. That block shifted bile making toward a backup path, and germ transplants backed a germ role in the fat gain. Readers get a joined diet-germ-liver story, still early.
Catalog record
| CREATOR | Jiayue Xia, Da Pan, Tianyu Wu, Zhiyuan Feng, Yanyan Tian, Zhi He, Zhenzhen Zhang, Yingqi Shao, Junhui Yu, Wei Yan, Jiongnan Wang, Shiyu Yin, Xingyi Jin, Yilu Chen, Yuanyuan Wang, Guiju Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 101 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |