Glycoproteomic Signatures of IgG Subclass N‐Glycosylation Reveal Molecular Endotypes in Idiopathic Inflammatory Myopathies
Tong Wu, Yanhong Li, Yingying Ling, Yinlan Wu, Jing Zhao, Lu Cheng, Chunyu Tan, Yi Zhang, Yong Zhang, Yi Liu · 2026
Read Glycoproteomic Signatures of IgG Subclass N‐Glycosylation Reveal Molecular Endotypes in Idiopathic Inflammatory Myopathies by Tong Wu, Yanhong Li, Yingying Ling, Yinlan Wu, Jing Zhao, Lu Cheng, Chunyu Tan, Yi Zhang, Yong Zhang, Yi Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13596912.txt.
Description
Tong Wu leads a ten-author team reading the sugar coatings on antibodies to sort idiopathic inflammatory myopathies, a family of autoimmune muscle diseases that no firm molecular test can sort. Looking back, the team profiled subclass-specific antibody glycosylation in blood from 145 patients and 52 healthy controls. They used mass spectrometry to do it.
Patients showed heavier core fucosylation and changes across thirteen antibody sugar forms. A clustering pass split patients into three sugar-defined endotypes dominated by muscle, skin, or joint disease, each with its own signs and blood profile. Certain antibody forms tracked with muscle injury markers and with complement deposits in tissue, hinting that the coatings help steer immune damage. A seven-marker model could assign patients to the types with fair success. The authors present these sugar patterns as a hidden layer of disease variety worth building tests on.
Catalog record
| CREATOR | Tong Wu, Yanhong Li, Yingying Ling, Yinlan Wu, Jing Zhao, Lu Cheng, Chunyu Tan, Yi Zhang, Yong Zhang, Yi Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |