The gut microbiota as a regulator of intestinal stem-cell fate: bacterial and fungal control of differentiation and regeneration
Yetong Shen, Benjamin James Chadwick, Peng Xue, Yiru Gao, Chen Ding · 2026
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Description
The gut renews its lining constantly from a pool of stem cells, and the microbes living nearby help steer that renewal. Yetong Shen and co-authors review what is known about bacterial and fungal influence on these stem cells: how they divide, which cell types they become, and how the gut repairs damage. Microbial chemicals and cell-wall pieces reach the stem cells directly or through immune messengers, switching pathways that control growth.
The reviewers are careful about strength of evidence. For bacteria, several pathways are well supported, though effects depend on the exact signal and tissue state. For fungi, the evidence is thinner: some fungal products engage repair pathways, but many studies show better barrier function without measuring stem cells at all. The authors map the gaps that future work should close.
Catalog record
| CREATOR | Yetong Shen, Benjamin James Chadwick, Peng Xue, Yiru Gao, Chen Ding |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |