Right ventricular pressure overload disturbs T-tubule maturation via MEF2D’s transcriptional regulation of BIN1
Yuqing Hu, Yiting Xue, Xudong Chen, Linghui Kong, Debao Li, Zheng Wang, Sixie Zheng, Siqi She, Hao Li, Sijuan Sun, Hao Chen, Lijun Chen · 2026
Read Right ventricular pressure overload disturbs T-tubule maturation via MEF2D’s transcriptional regulation of BIN1 by Yuqing Hu, Yiting Xue, Xudong Chen, Linghui Kong, Debao Li, Zheng Wang, Sixie Zheng, Siqi She, Hao Li, Sijuan Sun, Hao Chen, Lijun Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13596720.txt.
Description
Yuqing Hu and colleagues traced how pressure overload in the right side of a child's heart stalls the maturation of heart muscle cells. In samples from children with tetralogy of Fallot and in newborn rats with a banded lung artery, the tiny tunnels called T-tubules, which synchronize each heartbeat's contraction, failed to develop normally.
Gene activity scans showed tubule-related genes switched down, with Bin1, a builder of those tunnels, among the most suppressed. Restoring Bin1 in the banded rats rescued tubule maturation. The chain ran through chromatin. Pressure closed access to the Bin1 gene. A transcription factor, Mef2d, proved to be the brake. Silencing it freed Bin1, and mutating its binding sites erased its effect. The authors present the pathway as a therapeutic direction for children's heart diseases driven by right-sided pressure.
Catalog record
| CREATOR | Yuqing Hu, Yiting Xue, Xudong Chen, Linghui Kong, Debao Li, Zheng Wang, Sixie Zheng, Siqi She, Hao Li, Sijuan Sun, Hao Chen, Lijun Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |