PEDV envelope protein promotes viral replication by remodeling host iron homeostasis via the TRIM28-KLF15-FPN axis
Leyu Hu, Ru Tian, Lexi Gao, Ning Xu, Peizhen Li, Lijie Wang, Xingwei Fu, Zesheng Rong, Muzi Du, Yixuan Ma, Yue Cheng, Lu Han, Xin Ran, Guiwen Guan, Ting Zhou, Lingling Chang, Xiaomin Zhao, Qian Du, Yong Huang, Dewen Tong, Mingjun Zhu · 2026
Read PEDV envelope protein promotes viral replication by remodeling host iron homeostasis via the TRIM28-KLF15-FPN axis by Leyu Hu, Ru Tian, Lexi Gao, Ning Xu, Peizhen Li, Lijie Wang, Xingwei Fu, Zesheng Rong, Muzi Du, Yixuan Ma, Yue Cheng, Lu Han, Xin Ran, Guiwen Guan, Ting Zhou, Lingling Chang, Xiaomin Zhao, Qian Du, Yong Huang, Dewen Tong, Mingjun Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13595948.txt.
Description
Leyu Hu and a large team show how a pig diarrhea virus steals host iron to grow. Their study appeared in twenty twenty-six. The virus can kill all suckling piglets it hits and threats pig farms across the globe. Iron is key food for germs, and the sole iron exit in the body is a prime mark for such theft. Whether crown germs use that path was unknown.
The virus coat part traps a host gene switch in the cell soup and marks it for waste. With the switch gone, the iron exit gene falls, iron piles in cells, and the virus grows more. The team flags the chain as a drug aim for crown germs.
Catalog record
| CREATOR | Leyu Hu, Ru Tian, Lexi Gao, Ning Xu, Peizhen Li, Lijie Wang, Xingwei Fu, Zesheng Rong, Muzi Du, Yixuan Ma, Yue Cheng, Lu Han, Xin Ran, Guiwen Guan, Ting Zhou, Lingling Chang, Xiaomin Zhao, Qian Du, Yong Huang, Dewen Tong, Mingjun Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |