Biocatalytic Cascade from Geraniol to Enantiopure (R)‑Citronellal Using an Aryl-Alcohol Oxidase and Ene Reductase
Claudia Ferrer-Carbonell, Christian Ascaso-Alegre, Paula Cinca-Fernando, Patricia Ferreira, Juan Mangas-Sánchez, Caroline E. Paul · 2026
Read Biocatalytic Cascade from Geraniol to Enantiopure (R)‑Citronellal Using an Aryl-Alcohol Oxidase and Ene Reductase by Claudia Ferrer-Carbonell, Christian Ascaso-Alegre, Paula Cinca-Fernando, Patricia Ferreira, Juan Mangas-Sánchez, Caroline E. Paul (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13595905.txt.
Description
Citronellal, a lemon-scented building block for menthol, is usually made by harsh chemistry with poor control over its mirror forms. Claudia Ferrer-Carbonell and co-authors report a clean enzyme route in this 2026 paper. Two enzymes work in one pot: an oxidase from a Streptomyces species and a second enzyme from yeast, tuned by one amino acid change.
Starting from geraniol, a common plant alcohol, the pair produced the desired right-handed form of citronellal. A scaled run at high loading yielded 95 milligrams of product with purity above 99.8 percent for the chosen mirror form. The route is presented as a green, selective way to make this and related scent compounds. It avoids the waste of the standard chemical path.
Catalog record
| CREATOR | Claudia Ferrer-Carbonell, Christian Ascaso-Alegre, Paula Cinca-Fernando, Patricia Ferreira, Juan Mangas-Sánchez, Caroline E. Paul |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |