LIPUS-mediated mechanotransduction activates the YAP/TAZ/SCX axis and enhances tenogenesis-associated responses in tendon stem cells
Shangbin Li, Yang Hu, Kailun Zheng, Lixin Chen, Dijun Li, Yun Li · 2026
Read LIPUS-mediated mechanotransduction activates the YAP/TAZ/SCX axis and enhances tenogenesis-associated responses in tendon stem cells by Shangbin Li, Yang Hu, Kailun Zheng, Lixin Chen, Dijun Li, Yun Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13595827.txt.
Description
Shangbin Li and co-authors test, in a 2026 study, if soft pulsed ultrasound can push tendon stem cells to build tendon. Tendon heals in a poor way, with scar in place of strong tissue. Stem cells from tendon drive its repair. The signal from the sound waves, a force sense called mechanotransduction, was thought to run through the YAP and TAZ proteins. The team first read public gene data from cells that got the sound. Paths tied to force sense, cell frame, and YAP/TAZ all lit up in that data.
They then grew rat tendon stem cells and split them in three: no sound, sound, and sound plus a drug that blocks the path. Sound raised cell move and the marks of tendon build, such as SCX and type I collagen. The block drug cut those gains back. The axis is thus in the chain.
Catalog record
| CREATOR | Shangbin Li, Yang Hu, Kailun Zheng, Lixin Chen, Dijun Li, Yun Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |