cRGD-functionalized exosome–Mn₃O₄ nanoplatform enhanced ischemic lesion accumulation and ros scavenging-mediated neuroprotection in ischemic stroke
Xu Deng, Xixiang Xie, Xing Zhou, Lanfang Jiang, Tao Zhu, Rixiang Su, Chunmei Chen, Wan Chen, Chunxia Chen · 2026
Read cRGD-functionalized exosome–Mn₃O₄ nanoplatform enhanced ischemic lesion accumulation and ros scavenging-mediated neuroprotection in ischemic stroke by Xu Deng, Xixiang Xie, Xing Zhou, Lanfang Jiang, Tao Zhu, Rixiang Su, Chunmei Chen, Wan Chen, Chunxia Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13595739.txt.
Description
Xu Deng and co-authors build a targeted nanoplatform to protect the brain after ischemic stroke in this 2026 paper. Stroke treatment is limited because drugs reach the injured area poorly. Damage also keeps growing after blood flow returns, driven by reactive oxygen.
Their system starts with vesicles shed by neural stem cells. A ring-shaped peptide guides those vesicles toward the stroke lesion. Inside, mineral particles mop up the harmful reactive oxygen species. The hybrid design pairs homing with antioxidant defense. Tests show better build-up in lesions and stronger brain protection. Such platforms may one day carry other stroke drugs to the right place. Animal tests must still prove the gain holds at larger scale.
Catalog record
| CREATOR | Xu Deng, Xixiang Xie, Xing Zhou, Lanfang Jiang, Tao Zhu, Rixiang Su, Chunmei Chen, Wan Chen, Chunxia Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |