A tumor microenvironment acid-responsive therapy combining fenton chemistry and chemotherapy via TNF pathway for synergistic and safe lung cancer treatment
Cai Zhang, Long Zhang, Jing Tian, Jie Shi, Xiao Li, Tong Jiao, Xin Zhao, Bo Yuan, Lizhong Zeng, Yuanyuan Cheng, Umid Sunnatovich Mamedov, Laziz Nurkhonovich Niyazov, Shuanying Yang · 2026
Read A tumor microenvironment acid-responsive therapy combining fenton chemistry and chemotherapy via TNF pathway for synergistic and safe lung cancer treatment by Cai Zhang, Long Zhang, Jing Tian, Jie Shi, Xiao Li, Tong Jiao, Xin Zhao, Bo Yuan, Lizhong Zeng, Yuanyuan Cheng, Umid Sunnatovich Mamedov, Laziz Nurkhonovich Niyazov, Shuanying Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13595560.txt.
Description
Cai Zhang and co-authors published this lung cancer study in 2026. Chemo often fails lung tumors through resistance and whole-body harm. The team built a smart particle that wakes only in the tumor's acid bath. It joins lanthanum oxide, a dark polymer coat, and the chemo drug paclitaxel. In the acid, the particle frees the drug and stirs up reactive oxygen, the Fenton-style chemistry of the title.
In tests, the particle stalled tumor growth and pushed cells to self-destruct, halting their cycle and flipping life-and-death proteins. It also tuned an immune-linked TNF path and shifted immune marks in the tumor. Both skin-grown and spread tumors shrank, while organs and blood stayed sound. The authors call the blend of chemo, oxygen stress, and immune tuning a safe, strong plan.
Catalog record
| CREATOR | Cai Zhang, Long Zhang, Jing Tian, Jie Shi, Xiao Li, Tong Jiao, Xin Zhao, Bo Yuan, Lizhong Zeng, Yuanyuan Cheng, Umid Sunnatovich Mamedov, Laziz Nurkhonovich Niyazov, Shuanying Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |