Advances in skin aging: integrating epigenetic, cellular, and immune mechanisms for targeted therapy
Jinxuan Su, Hongzhong Jin · 2026
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Description
Jinxuan Su and Hongzhong Jin review skin aging as a connected system rather than a list of separate faults, organizing the mechanisms at three levels. Their 2026 synthesis begins with chemical marks on DNA that drift with age and lock in worn-out gene programs, then moves to exhausted cells and their remodeled energy factories.
At the tissue level, the cleanup of those exhausted cells falters as the immune system itself ages. The stranded cells pump out inflammatory signals. Those signals keep the skin in a state of low-grade irritation. They also break down its supporting matrix. Each level feeds the next, the authors argue. Against that map they set the emerging toolkit. It includes drugs that clear or quiet senescent cells, epigenetic and mitochondrial modulators, biologics, and immune therapies. Regenerative and device-based approaches complete the list. Together they sketch where targeted treatment of aging skin might go.
Catalog record
| CREATOR | Jinxuan Su, Hongzhong Jin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73563 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |