Effectiveness of amisulpride augmentation versus other antipsychotics in clozapine-treated adolescents: a real-world retrospective study
Binay Kayan Ocakoglu, Ayşegül Tonyalı, Uğur Karabağ, Zeynep Gültekin Taş, Damla Kasap Üstündağ, Gül Karaçetin · 2026
Read Effectiveness of amisulpride augmentation versus other antipsychotics in clozapine-treated adolescents: a real-world retrospective study by Binay Kayan Ocakoglu, Ayşegül Tonyalı, Uğur Karabağ, Zeynep Gültekin Taş, Damla Kasap Üstündağ, Gül Karaçetin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13595519.txt.
Description
Binay Kayan Ocakoglu and five co-authors compare add-on drugs for teens treated with clozapine in this 2026 study. Clozapine is a strong drug for schizophrenia that is used when others fail. Doctors often add a second drug, but which add-on works best for young patients is unclear.
The team reviewed seventy-six young inpatients treated at a Turkish hospital between 2013 and 2023. Twenty-two got amisulpride as the add-on and fifty-four got other drugs. Symptom scores fell by about the same amount in both groups by discharge. Response rates were also similar. Higher clozapine dose and worse starting symptoms predicted bigger gains. The authors warn that heavy add-on doses may blunt recovery from negative symptoms.
Catalog record
| CREATOR | Binay Kayan Ocakoglu, Ayşegül Tonyalı, Uğur Karabağ, Zeynep Gültekin Taş, Damla Kasap Üstündağ, Gül Karaçetin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |