Longitudinal Associations Between Inflammation and Multi‐Dimensional Fatigue up to 2 Years After Colorectal Cancer Diagnosis
Anouk E C Bruijnzeels, Floortje Mols, Katrijn Van Deun, Dounya Schoormans · 2026
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Description
Anouk E C Bruijnzeels and colleagues followed colorectal cancer survivors for two years to test whether inflammation tracks the many faces of cancer fatigue. Within a population-based Dutch study, 411 newly diagnosed patients gave blood and answered fatigue questionnaires at diagnosis, one year, and two years, alongside a matched comparison group without cancer.
Eleven inflammation markers were measured. The soluble TNF receptors related most consistently to nearly every fatigue dimension. Those receptors are signals tied to a master inflammatory switch. The dimensions covered general, physical, and mental fatigue, plus reduced activity and motivation. Other markers joined in for specific dimensions, and mental fatigue showed the steadiest pattern. Survivors displayed a broader inflammation-fatigue web than the comparison group. The authors see inflammation as a plausible lever for easing survivorship fatigue, with the TNF pathway first in line.
Catalog record
| CREATOR | Anouk E C Bruijnzeels, Floortje Mols, Katrijn Van Deun, Dounya Schoormans |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56974 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |